Description: Coronary Tone in Ischemic Heart Disease by W. Kupper, W. Bleifeld, R.N. MacAlpin Estimated delivery 3-12 business days Format Hardcover Condition Brand New Description W. KUPPER Coronary artery vasoconstriction is not only the mechanism responsible for Prinzmetals variant angina, but may also be involved in stable angina pectoris and myocardial infarction. However, the underlying patho-physiological mecha nisms and the importance of coronary vasoconstriction in these syndromes is still largely unknown. Several hypotheses have been proposed. Sympathetic nervous activity plays a key role in the regulation of coronary blood flow, but mechanical or humoral constrictive factors may be active as well. a-adrenergic tone Adrenergic nerve fibers accompany coronary vessels of any size. The stimulation of cardiac sympathetic nerves causes an increase in coronary blood flow. If, however, chronotropic and inotropic effects of adrenergic stimulation are sup pressed pharmacologically by beta-adrenoceptor blockade, a reduction in flow is observed. Thus, the primary effect of sympathetic stimulation on the coronary arteries is the alpha-adrenergic mediated vasoconstriction. Functionally inner vated alpha-adrenoceptors have been documented both in large coronary con ductance arteries and in the small resistance vessels. Animal studies and a human study have documented that a permanent constrictor tone is present on the coronary circulation both at rest and during exercise; this condition could be prevented with alpha-adrenoceptor blockade or was absent after heart transplan tation. Therefore, alpha-adrenoceptor mediated coronary constriction is an at tractive hypothesis as a possible pathophysiological mechanism of inappropriate coronary vasoconstriction and cororiary vaso Publisher Description W. KUPPER Coronary artery vasoconstriction is not only the mechanism responsible for Prinzmetals variant angina, but may also be involved in stable angina pectoris and myocardial infarction. However, the underlying patho-physiological mecha- nisms and the importance of coronary vasoconstriction in these syndromes is still largely unknown. Several hypotheses have been proposed. Sympathetic nervous activity plays a key role in the regulation of coronary blood flow, but mechanical or humoral constrictive factors may be active as well. a-adrenergic tone Adrenergic nerve fibers accompany coronary vessels of any size. The stimulation of cardiac sympathetic nerves causes an increase in coronary blood flow. If, however, chronotropic and inotropic effects of adrenergic stimulation are sup- pressed pharmacologically by beta-adrenoceptor blockade, a reduction in flow is observed. Thus, the primary effect of sympathetic stimulation on the coronary arteries is the alpha-adrenergic mediated vasoconstriction. Functionally inner- vated alpha-adrenoceptors have been documented both in large coronary con- ductance arteries and in the small resistance vessels.Animal studies and a human study have documented that a permanent constrictor tone is present on the coronary circulation both at rest and during exercise; this condition could be prevented with alpha-adrenoceptor blockade or was absent after heart transplan- tation. Therefore, alpha-adrenoceptor mediated coronary constriction is an at- tractive hypothesis as a possible pathophysiological mechanism of inappropriate coronary vasoconstriction and cororiary vasospasm. Details ISBN 0898386462 ISBN-13 9780898386462 Title Coronary Tone in Ischemic Heart Disease Author W. Kupper, W. Bleifeld, R.N. MacAlpin Format Hardcover Year 1984 Pages 130 Edition 1984th Publisher Kluwer Academic Publishers GE_Item_ID:151479519; About Us Grand Eagle Retail is the ideal place for all your shopping needs! With fast shipping, low prices, friendly service and over 1,000,000 in stock items - you're bound to find what you want, at a price you'll love! Shipping & Delivery Times Shipping is FREE to any address in USA. Please view eBay estimated delivery times at the top of the listing. Deliveries are made by either USPS or Courier. We are unable to deliver faster than stated. International deliveries will take 1-6 weeks. NOTE: We are unable to offer combined shipping for multiple items purchased. This is because our items are shipped from different locations. Returns If you wish to return an item, please consult our Returns Policy as below: Please contact Customer Services and request "Return Authorisation" before you send your item back to us. Unauthorised returns will not be accepted. 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Price: 125.87 USD
Location: Fairfield, Ohio
End Time: 2025-01-24T03:14:20.000Z
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Refund will be given as: Money Back
ISBN-13: 9780898386462
Book Title: Coronary Tone in Ischemic Heart Disease
Number of Pages: IX, 130 Pages
Language: English
Publication Name: Coronary Tone in Ischemic Heart Disease
Publisher: Springer Netherlands
Publication Year: 1984
Subject: Cardiology
Item Weight: 30.7 Oz
Type: Textbook
Item Length: 9.3 in
Author: Rex N. Macalpin
Subject Area: Medical
Series: Developments in Cardiovascular Medicine Ser.
Item Width: 6.1 in
Format: Hardcover
